Friend or foe? Turning a host defense protein into a pathogen's accomplice.

نویسندگان

  • Aimee Shen
  • Matthew Bogyo
چکیده

Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it into a cofactor that enhances proteolytic destruction of host-defense antibodies.

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عنوان ژورنال:
  • Chemistry & biology

دوره 15 9  شماره 

صفحات  -

تاریخ انتشار 2008